de Oliveira J A
Department of Ophthalmology and Otorhinolaryngology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil.
Rev Laryngol Otol Rhinol (Bord). 1990;111(5):491-6.
Ototoxic drugs, the best known of which are aminoglucoside antibiotics, can cause irreversible lesions in the ciliate cells of the organ of Corti and the maculae and crests of the vestibular apparatus. The cellular lesion is linked to the formation of complex substances between the ototoxic drug and the polyphospho-inositides of the cellular membrane. Auditory and vestibular monitoring must be ensured permanently throughout the use of such drugs, especially in the presence of risk factors. The lesions induced experimentally in animals having studied by electrophysiological methods, with recordings of the cochlear and brainstem potentials, and by histological methods with the technique of surface preparation of the organ of Corti, and by electron microscopy.
耳毒性药物，其中最广为人知的是氨基糖苷类抗生素，可导致柯蒂氏器的纤毛细胞以及前庭器官的斑和嵴出现不可逆损伤。细胞损伤与耳毒性药物和细胞膜的多磷酸肌醇之间形成复合物有关。在使用此类药物的整个过程中，必须始终确保进行听觉和前庭监测，尤其是在存在危险因素的情况下。通过电生理方法记录耳蜗和脑干电位、采用柯蒂氏器表面制备技术的组织学方法以及电子显微镜，对动物进行了实验性诱导损伤的研究。
