Department of Neurology, Henry Ford Health System, Detroit, Mich 48202, USA.
Stroke. 2010 Oct;41(10 Suppl):S112-3. doi: 10.1161/STROKEAHA.110.595629.
We discuss the use of MRI in detecting and staging white matter reorganization after brain injury with and without neurorestorative treatment. Based on variations of diffusion tensor MRI (DTI) methodology, we demonstrate that MRI can detect white matter remodeling after brain injury. In addition, we demonstrate that Q-space DTI can detect early stage axonal remodeling, which involves randomly oriented crossing axons. With the information obtained from conventional and Q-space DTI, it is possible to stage white matter remodeling after brain injury.
我们讨论了 MRI 在检测和分期脑损伤后有无神经修复治疗的白质重组中的应用。基于扩散张量 MRI(DTI)方法的变化,我们证明 MRI 可以检测脑损伤后的白质重塑。此外,我们还证明了 Q 空间 DTI 可以检测早期的轴突重塑,其中包括随机定向的交叉轴突。通过常规和 Q 空间 DTI 获得的信息,可以对脑损伤后的白质重塑进行分期。