Division of Medicine, Imperial College London, London, UK.
Gut. 2011 Feb;60(2):268-78. doi: 10.1136/gut.2010.212555. Epub 2010 Sep 28.
In 1989, hepatitis C virus (HCV) was first identified as the infectious agent responsible for human non-A, non-B hepatitis. Two decades later, HCV remains a global public health problem with a suboptimal response rate to treatment and the absence of a protective vaccine. Recent work has highlighted the influence of the innate immune system, and in particular natural killer cells, on the outcome and pathology of HCV infection. These cells are considerably more complex than was originally thought and their role in viral infections is currently being unravelled. This review summarises our emerging understanding of natural killer cells in HCV infection.
1989 年，丙型肝炎病毒（HCV）首次被确定为导致人类非甲非乙型肝炎的病原体。二十年后，HCV 仍然是一个全球性的公共卫生问题，其治疗反应率不理想，且缺乏保护性疫苗。最近的研究强调了先天免疫系统，特别是自然杀伤细胞，对 HCV 感染结局和发病机制的影响。这些细胞比最初认为的要复杂得多，它们在病毒感染中的作用目前正在被揭示。本文综述了我们对 HCV 感染中自然杀伤细胞的理解。
