Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
J Clin Invest. 2010 Oct;120(10):3434-7. doi: 10.1172/JCI44810. Epub 2010 Sep 27.
Voltage-gated Na(+) channels (VGSCs) are responsible for the rising phase of the action potential in excitable cells, including neurons and skeletal and cardiac myocytes. Small alterations in gating properties can lead to severe changes in cellular excitability, as evidenced by the plethora of heritable conditions attributed to mutations in VGSCs highlighting the need to better understand VGSC regulation. In this issue of the JCI, Hund et al. identify the ability of a key structural protein, β(IV)-spectrin, to bind and recruit Ca(2+)/calmodulin kinase II to the channel at a cellular location key to successful action potential initiation and propagation, where it can mediate function and excitability.
电压门控钠离子通道（VGSCs）负责可兴奋细胞（包括神经元、骨骼肌和心肌细胞）动作电位的上升相。门控特性的微小改变可导致细胞兴奋性的严重改变，这可由大量遗传性疾病归因于 VGSCs 突变得到证明，这凸显了更好地理解 VGSC 调节的必要性。在本期 JCI 中，Hund 等人发现关键结构蛋白β(IV)- spectrin 能够结合并募集 Ca(2+)/钙调蛋白激酶 II 至通道，这一位置对于成功的动作电位起始和传播至关重要，在该处它可介导功能和兴奋性。
