Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA.
Nat Neurosci. 2010 Oct;13(10):1161-9. doi: 10.1038/nn.2647. Epub 2010 Sep 27.
Modeling of human neuropsychiatric disorders in animals is extremely challenging given the subjective nature of many symptoms, the lack of biomarkers and objective diagnostic tests, and the early state of the relevant neurobiology and genetics. Nonetheless, progress in understanding pathophysiology and in treatment development would benefit greatly from improved animal models. Here we review the current state of animal models of mental illness, with a focus on schizophrenia, depression and bipolar disorder. We argue for areas of focus that might increase the likelihood of creating more useful models, at least for some disorders, and for explicit guidelines when animal models are reported.
鉴于许多精神症状的主观性、生物标志物和客观诊断测试的缺乏，以及相关神经生物学和遗传学的早期状态，在动物中对人类神经精神疾病进行建模极具挑战性。尽管如此，对病理生理学的理解和治疗开发的进展将极大地受益于改进的动物模型。在这里，我们回顾了精神疾病的动物模型的现状，重点是精神分裂症、抑郁症和双相情感障碍。我们认为，关注一些可能增加创建更有用模型的可能性的领域，至少对于某些疾病而言，以及在报告动物模型时明确指南是有必要的。
