Cardiology Division, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 2010 Nov;51(6):971-3. doi: 10.3349/ymj.2010.51.6..
Weight-control drugs (known as anorexigens) such as fenfluramine have been linked with pulmonary hypertension in previous reports. In our case, a 29 year old woman was admitted for shortness of breath and was diagnosed with pulmonary hypertension. Three months ago, she had been taking phentermine for five weeks. Other factors that might have contributed to the development of pulmonary hypertension were excluded. With treatment, her symptoms improved. This is the first case that can suggest a possible connection between phenermine single medication with pulmonary hypertension. Phentermine has been considered a relatively safe drug to treat obesity, and further investigation is needed to decide the safety and dosage of phentermine.
在之前的报告中，像芬氟拉明这样的减肥药（亦称食欲抑制剂）与肺动脉高压有关。在我们的病例中，一位 29 岁女性因呼吸急促入院，并被诊断为肺动脉高压。三个月前，她曾服用苯丁胺五周。其他可能导致肺动脉高压的因素已被排除。经过治疗，她的症状有所改善。这是首例可能表明苯丁胺单一药物与肺动脉高压之间存在关联的病例。苯丁胺一直被认为是治疗肥胖症相对安全的药物，需要进一步研究来确定苯丁胺的安全性和剂量。
