Suzuki Eiji, Kyozuka Hyo, Nishida Toru, Kanno Takashi, Ohira Hiromasa
Division of Rheumatology, Ohta-Nishinouchi Hospital, 2-5-20 Nishinouchi, Koriyama, Fukushima 963-8022, Japan.
Mod Rheumatol. 2009;19(4):447-51. doi: 10.1007/s10165-009-0184-y. Epub 2009 Jun 6.
A 20-year-old woman was admitted to our hospital because of bilateral pretibial edema. Administration of prednisolone was started after she was diagnosed with systemic lupus erythematosus (SLE). However, skin ulcers on her extremities developed; they subsequently worsened with tapering of prednisolone. She also developed pulmonary hypertension (PH). Her skin ulcers improved considerably after administration of bosentan, an endothelin receptor antagonist. Bosentan may be efficacious not only for PH but also for refractory skin ulcers.
一名20岁女性因双侧胫前水肿入院。在被诊断为系统性红斑狼疮（SLE）后开始使用泼尼松龙治疗。然而，她的四肢出现了皮肤溃疡；随后随着泼尼松龙剂量的逐渐减少，溃疡病情恶化。她还出现了肺动脉高压（PH）。在使用内皮素受体拮抗剂波生坦治疗后，她的皮肤溃疡有了明显改善。波生坦可能不仅对肺动脉高压有效，对难治性皮肤溃疡也有效。
