Fedin A I, Kaluga A S, Mironova O P, Solov'eva E Iu
Zh Nevrol Psikhiatr Im S S Korsakova. 2009;109(12 Suppl 2):8-12.
One hundred and twenty-one patients (mean age 64.13 +/- 8.43 years) with the diagnosis of chronic cerebral ischemia were examined. Somatic and neurological examinations, biochemical blood test, plasma homocysteine measurement, CKT/MRI were carried out. Neuropsychological tests (the MMSE, a battery of frontal dysfunction tests (BFDT), the Clock drawing test, the test of speech activity, the five words test, semantic and categorical associations, the Tailor Manifest Anxiety Scale) were administered: Patients were stratified into 3 groups: group 1 included 34 patients with confirmed cognitive disorders and mild hyperhomocysteinemia (> 15 mcmol/l); group 2 consisted of 51 patients with cognitive disorders and normal levels of homocysteine (< 15 mcmol/l) and group 3 consisted of 36 controls without cognitive disorders and with normal levels of homocysteine. In group 1, the performance of neuropsychological tests was significantly lower and neurological deficit was the most severe. We found reverse correlations between homocysteine levels and severity of cognitive disorders, which were most strong for the results of BFDT, the clock drawing test and the test of speech activity. Hyperhomocysteinemia was positively correlated with the worse values of neurological status and severity of chronic cerebral ischemia.
对121例诊断为慢性脑缺血的患者（平均年龄64.13±8.43岁）进行了检查。进行了体格和神经学检查、血液生化检测、血浆同型半胱氨酸测量、CTK/MRI检查。实施了神经心理学测试（简易精神状态检查表（MMSE）、一系列额叶功能障碍测试（BFDT）、画钟试验、言语活动测试、五个单词测试、语义和范畴联想、泰勒显性焦虑量表）：患者被分为3组：第1组包括34例确诊为认知障碍且伴有轻度高同型半胱氨酸血症（>15 μmol/l）的患者；第2组由51例有认知障碍且同型半胱氨酸水平正常（<15 μmol/l）的患者组成，第3组由36例无认知障碍且同型半胱氨酸水平正常的对照者组成。在第1组中，神经心理学测试的表现显著较低，神经功能缺损最为严重。我们发现同型半胱氨酸水平与认知障碍的严重程度呈负相关，这在BFDT、画钟试验和言语活动测试的结果中最为明显。高同型半胱氨酸血症与神经状态较差值和慢性脑缺血的严重程度呈正相关。
