黑色素对脂质体膜中卵磷脂氧化的影响。
The effect of melanins on oxidation of lecithin in liposomal membranes.
作者信息
Porebska-Budny M, Stepień K
机构信息
Department of Biochemistry and Biophysics, Silesian Medical Academy, Sosnowiec, Poland.
出版信息
Acta Biochim Pol. 1990;37(1):89-92.
Lecithin peroxidation in liposomal membranes induced by UV light was studied in the presence of natural eye melanin and synthetic melanins prepared from various precursors. It was shown that melanins inhibited lecithin photooxidation, and that the extent of this effect strongly depended on the type and concentration of melanin. Comparative study indicated that melanin obtained from adrenolutin was the most effective antioxidant. The ability to inhibit lipid peroxidation depends both on the concentration of paramagnetic centers in the melanin polymer and the accessibility of these centers for free radicals formed during irradiation of liposomes.
在天然眼黑色素和由各种前体制备的合成黑色素存在的情况下，研究了紫外线诱导的脂质体膜中卵磷脂的过氧化作用。结果表明，黑色素抑制了卵磷脂的光氧化作用，并且这种作用的程度强烈依赖于黑色素的类型和浓度。比较研究表明，从肾上腺素红获得的黑色素是最有效的抗氧化剂。抑制脂质过氧化的能力既取决于黑色素聚合物中顺磁中心的浓度，也取决于这些中心对于脂质体辐照过程中形成的自由基的可及性。
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