Sakina N L, Dontsov A E, Kuznetsova G P, Ostrovskiĭ M A, Archakov A I
Biokhimiia. 1980 Aug;45(8):1476-80.
The effects of melanoprotein granules of the eye pigment epithelium and synthetic melanin on lipid peroxidation in rat liver microsomes and azolectin liposomes were studied. It was shown that lipid peroxidation in the microsomes and liposomes induced by ascorbate or the Fe2+ + ascorbate system is effectively inhibited by the melanoprotein granules and synthetic melanin. The enzymatic lipid peroxidation in the microsomes induced by NADPH and NADPH + Fe2+ is insensitive to the effect of the melanoprotein granules, but is inhibited by synthetic melanin. It is assumed that melanin is mainly responsible for the inhibitory action of the melanoprotein granules.
研究了眼色素上皮黑素蛋白颗粒和合成黑色素对大鼠肝微粒体及卵磷脂脂质体脂质过氧化的影响。结果表明，抗坏血酸或Fe2+ +抗坏血酸体系诱导的微粒体和脂质体中的脂质过氧化可被黑素蛋白颗粒和合成黑色素有效抑制。NADPH和NADPH + Fe2+诱导的微粒体中的酶促脂质过氧化对黑素蛋白颗粒的作用不敏感，但可被合成黑色素抑制。推测黑色素是黑素蛋白颗粒抑制作用的主要原因。
