Department of Nuclear Engineering and Management, Graduate School of Engineering, University of Tokyo, Japan.
Med Phys. 2010 Aug;37(8):4445-55. doi: 10.1118/1.3462559.
The purpose of this study is to verify the characteristics of the positron emitter nuclei generated at each treatment site by proton irradiation.
Proton therapy using a beam on-line PET system mounted on a rotating gantry port (BOLPs-RGp), which the authors developed, is provided at the National Cancer Center Kashiwa, Japan. BOLPs-RGp is a monitoring system that can confirm the activity distribution of the proton irradiated volume by detection of a pair of annihilation gamma rays coincidentally from positron emitter nuclei generated by the target nuclear fragment reactions between irradiated proton nuclei and nuclei in the human body. Activity is measured from a start of proton irradiation to a period of 200 s after the end of the irradiation. The characteristics of the positron emitter nuclei generated in a patient's body were verified by the measurement of the activity distribution at each treatment site using BOLPs-RGp.
The decay curves for measured activity were able to be approximated using two or three half-life values regardless of the treatment site. The activity of half-life value of about 2 min was important for a confirmation of the proton irradiated volume.
In each proton treatment site, verification of the characteristics of the generated positron emitter nuclei was performed by using BOLPs-RGp. For the monitoring of the proton irradiated volume, the detection of (15)O generated in a human body was important.
本研究旨在验证通过质子辐照在每个治疗部位产生的正电子发射核的特性。
日本国立癌症中心柏市提供了一种使用安装在旋转机架端口上的在线束正电子发射断层扫描（BOLPs-RGp）系统的质子治疗，这是作者开发的一种监测系统，可以通过检测来自目标核碎片反应中辐照质子核与人体内核之间产生的正电子发射核的一对湮没伽马射线的同时性来确认质子辐照体积的活性分布。从开始辐照质子到辐照结束后 200 秒的时间段内进行活性测量。通过使用 BOLPs-RGp 在每个治疗部位测量活性分布，验证了在患者体内产生的正电子发射核的特性。
无论治疗部位如何，测量活性的衰减曲线都可以用两个或三个半衰期值来近似。半衰期约 2 分钟的活性对于确认质子辐照体积非常重要。
通过使用 BOLPs-RGp 在每个质子治疗部位验证了产生的正电子发射核的特性。对于质子辐照体积的监测，检测人体内产生的（15）O 非常重要。
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