Center for Advanced Medical Imaging Sciences, NMMI Division, Radiology Department, Massachusetts General Hospital, Harvard Medical School, Boston.
Theranostics. 2013 Sep 19;3(10):731-40. doi: 10.7150/thno.5162.
Proton therapy is very sensitive to uncertainties introduced during treatment planning and dose delivery. PET imaging of proton induced positron emitter distributions is the only practical approach for in vivo, in situ verification of proton therapy. This article reviews the current status of proton therapy verification with PET imaging. The different data detecting systems (in-beam, in-room and off-line PET), calculation methods for the prediction of proton induced PET activity distributions, and approaches for data evaluation are discussed.
质子治疗对治疗计划和剂量传递过程中引入的不确定性非常敏感。质子引发正电子放射性核素分布的正电子发射断层成像（PET）是质子治疗进行体内、原位验证的唯一实用方法。本文综述了目前利用 PET 成像对质子治疗进行验证的现状。讨论了不同的数据检测系统（束内、室内和离线 PET）、预测质子引起的 PET 活性分布的计算方法，以及数据评估方法。
