Center for Childhood Cancer, The Research Institute at Nationwide Children's Hospital, Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH 43205, USA.
Anticancer Agents Med Chem. 2010 Sep;10(7):512-9. doi: 10.2174/187152010793498636.
Glioblastoma (GBM) is the most common type of primary malignant brain tumor. Despite advances in surgical resection, radiotherapy and chemotherapy, prognosis remains very poor. Accordingly, recent studies have been focused on the aberrant signal transduction pathways in glioblastoma. Many patient derived primary glioblastomas and cell lines express constitutively activated signal transducers and activators of transcription 3 (STAT3). Here we focused on the recent progresses regarding to the roles of STAT3 in glioblastoma and glioblastoma stem cells (GBM-SCs), the dysregulation of STAT3 in glioblastoma, and targeting STAT3 for glioblastoma therapy.
胶质母细胞瘤（GBM）是最常见的原发性恶性脑肿瘤。尽管在手术切除、放疗和化疗方面取得了进展，但预后仍然很差。因此，最近的研究集中在胶质母细胞瘤中异常的信号转导途径上。许多患者来源的原发性胶质母细胞瘤和细胞系表达组成性激活的信号转导子和转录激活子 3（STAT3）。在这里，我们重点介绍了 STAT3 在胶质母细胞瘤和胶质母细胞瘤干细胞（GBM-SC）中的作用、STAT3 在胶质母细胞瘤中的失调以及针对 STAT3 进行胶质母细胞瘤治疗的最新进展。
