Füzes I
National Institute of Neurosurgery, Budapest, Hungary.
Acta Physiol Hung. 1990;76(1):27-48.
Based on the assumption that the maintenance of the energy content of the living tissue was the goal of the control, a generalized model of the regulation of local circulation was developed. The goodness of the model realised on a microcomputer was verified by the good fits of simulation with various physiological reactions obtained in animal experiments that were performed in cats anaesthetized with alpha-chloralose (50 mg/kg, i.v.). The reactions were elicited by tilting the animal (45 degrees head up) and by obstructing hindlimb blood flow by means of inflation of a pressure cuff. The appropriateness of energetic considerations of the hypothesis and the properness of the construction of the model was confirmed also by the similarity of the simulated static and dynamic pressure-flow and flow-temperature characteristics, respectively, with those obtained in animal experiments reported in the literature. The performance of the model suggests that the well-known regulatory phenomena of the local circulation are the results of a set point-free control system.
基于维持活组织能量含量是控制目标这一假设，建立了局部循环调节的通用模型。在以α-氯醛糖（50毫克/千克，静脉注射）麻醉的猫身上进行动物实验，获得了各种生理反应，通过模拟与这些反应的良好拟合，验证了在微型计算机上实现的模型的有效性。这些反应是通过将动物倾斜（头部向上45度）以及通过压力袖带充气阻碍后肢血流引发的。该假设在能量方面的考量的合理性以及模型构建的正确性，还分别通过模拟的静态和动态压力-流量以及流量-温度特性与文献中报道的动物实验结果的相似性得到了证实。该模型的性能表明，局部循环中众所周知的调节现象是无设定点控制系统的结果。
