[Local circulatory regulation: the characteristics of the behavior of vascular smooth muscles].

The general law of local regulation of the circulation and the "law of behaviour" of vascular smooth muscle are proposed on the basis of precise definition of hierarchically interrelated aims of the circulation: 1) stabilization of substances and heat fluxes through the tissue, 2) stabilization of the tissue environment at farthest points from the supplying vessels, and 3) minimization of circulating blood volume. The laws allow to unite modern theories of metabolic, myogenic and neurogenic regulation of vascular tone. A mathematical model of the vascular bed functioning in accordance with these laws, simulates the behaviour of real preparations in changes of arterial, venous or tissue pressure as well as of arterial blood composition and tissue metabolism. Sympathetic stimulation or denervation are also taken into consideration.