载脂蛋白 E 基因多态性与缺血性脑卒中患者颈动脉粥样硬化斑块稳定性的相关性
Monocyte chemoattractant protein (MCP-1) A-2518G gene polymorphism in stroke patients with different comorbidities.
机构信息
Department of Neurology, Medical University of Lublin, Lublin, Poland.
出版信息
Clin Biochem. 2010 Dec;43(18):1421-6. doi: 10.1016/j.clinbiochem.2010.09.011. Epub 2010 Sep 27.
OBJECTIVES
The aim of our study was to assess the effect of A-2518G polymorphism in the monocyte chemoattractant protein-1 gene on development of stroke.
DESIGN AND METHODS
A total of 194 patients with stroke and 320 healthy controls were genotyped for the MCP-1 gene -2518 polymorphism.
RESULTS
There was a significant difference in genotype frequencies between ischemic stroke patients and controls (p=0.01). Stroke patients were subdivided according to gender, presence of renal disease, small-vessel disease, diabetes, atherosclerosis and hyperlipidemia. There were differences in genotype frequencies between stroke patients with atherosclerosis and controls (p=0.03), and in allele frequencies between diabetic patients and controls (p=0.04). In hyperlipidemia, the OR 2.33 for the GG genotype may be due to stroke, because it was found only vs. controls and not vs. group without hyperlipidemia.
CONCLUSIONS
Our results demonstrate an association between the polymorphism in the regulatory region of MCP-1 gene and susceptibility to ischemic stroke.
目的
本研究旨在评估单核细胞趋化蛋白-1 基因 A-2518G 多态性对卒中发生的影响。
设计与方法
共对 194 例卒中患者和 320 例健康对照者进行 MCP-1 基因-2518 多态性的基因分型。
结果
缺血性卒中患者与对照组之间基因型频率存在显著差异（p=0.01）。根据性别、是否存在肾病、小血管疾病、糖尿病、动脉粥样硬化和高脂血症对卒中患者进行亚组分析。卒中合并动脉粥样硬化患者与对照组之间基因型频率存在差异（p=0.03），糖尿病患者与对照组之间等位基因频率存在差异（p=0.04）。在高脂血症中，GG 基因型的 OR 2.33 可能与卒中有关，因为仅在与对照组比较时发现，而与无高脂血症组比较时未发现。
结论
我们的结果表明，MCP-1 基因调控区的多态性与缺血性卒中的易感性相关。
Zotero 插件