Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences.
J Epidemiol. 2013;23(6):457-65. doi: 10.2188/jea.je20130054. Epub 2013 Sep 28.
Inflammatory gene polymorphisms are potentially associated with atherosclerosis risk, but their age-related effects are unclear. To investigate the age-related effects of inflammatory gene polymorphisms on arterial stiffness, we conducted cross-sectional and 5-year follow-up studies using the cardio-ankle vascular index (CAVI) as a surrogate marker of arterial stiffness.
We recruited 1850 adults aged 34 to 69 years from the Japanese general population. Inflammatory gene polymorphisms were selected from NF-kB1, CD14, IL-6, IL-10, MCP-1, ICAM-1, and TNF-α. Associations of CAVI with genetic and conventional risk factors were estimated by sex and age group (34-49, 50-59, and 60-69 years) using a general linear model. The association with 5-year change in CAVI was examined longitudinally.
Glucose intolerance was associated with high CAVI among women in all age groups, while hypertension was associated with high CAVI among participants in all age groups, except younger women. Mean CAVI for the CD14 CC genotype was lower than those for the TT and CT genotypes (P for trend = 0.005), while the CD14 polymorphism was associated with CAVI only among men aged 34 to 49 years (P = 0.006). No association of the other 6 polymorphisms with CAVI was observed. No association with 5-year change in CAVI was apparent.
Inflammatory gene polymorphisms were not associated with arterial stiffness. To confirm these results, further large-scale prospective studies are warranted.
炎症基因多态性可能与动脉粥样硬化风险相关，但它们与年龄的关系尚不清楚。为了研究炎症基因多态性与动脉僵硬度的年龄相关性，我们使用心血管-踝部血管指数（CAVI）作为动脉僵硬度的替代标志物进行了横断面和 5 年随访研究。
我们从日本一般人群中招募了 1850 名年龄在 34 至 69 岁的成年人。从 NF-kB1、CD14、IL-6、IL-10、MCP-1、ICAM-1 和 TNF-α 中选择炎症基因多态性。使用一般线性模型，根据性别和年龄组（34-49、50-59 和 60-69 岁）估计 CAVI 与遗传和常规危险因素的相关性。使用纵向研究方法检查与 CAVI 5 年变化的相关性。
葡萄糖耐量异常与所有年龄组女性的高 CAVI 相关，而高血压与所有年龄组参与者的高 CAVI 相关，除了年轻女性。CD14 CC 基因型的平均 CAVI 低于 TT 和 CT 基因型（趋势 P = 0.005），而 CD14 多态性仅与 34 至 49 岁的男性 CAVI 相关（P = 0.006）。其他 6 种多态性与 CAVI 无相关性。5 年 CAVI 变化无相关性。
炎症基因多态性与动脉僵硬度无关。为了证实这些结果，需要进行进一步的大规模前瞻性研究。
