Le Besnerais M, François A, Leroy F, Janvresse A, Levesque H, Marie I
Département de médecine interne, CHU de Rouen-Boisguillaume, 1 rue de Germont, Rouen cedex, France.
Rev Med Interne. 2011 Jan;32(1):3-8. doi: 10.1016/j.revmed.2010.08.015. Epub 2010 Sep 28.
Renal involvement is uncommon in sarcoidosis, occurring in less than 5% of the patients. Diagnostic delay should be minimal to improve the outcome.
From 1996 to 2009, 78 patients were seen for sarcoidosis in the Department of Internal Medicine of Rouen University hospital.
Five patients (6.4%) had renal involvement. Diagnosis of renal involvement and sarcoidosis were concomitant in two patients while in the three remaining patients, renal manifestations occurred during the course of sarcoidosis. The five patients with renal manifestations exhibited: isolated sarcoid granulomatous interstitial nephritis (n=2), sarcoid granulomatous interstitial nephritis and nephrocalcinosis (n=2), renal failure due to hypercalcemia (n=1).
This series underlines that renal function tests should be performed systematically both during initial evaluation and the follow-up of patients with sarcoidosis.
结节病累及肾脏的情况并不常见，发生率低于5%的患者。为改善预后，诊断延误应降至最低。
1996年至2009年，鲁昂大学医院内科诊治了78例结节病患者。
5例（6.4%）患者出现肾脏受累。2例患者肾脏受累与结节病的诊断同时出现，而其余3例患者的肾脏表现出现在结节病病程中。5例有肾脏表现的患者表现为：孤立性结节病肉芽肿性间质性肾炎（n = 2）、结节病肉芽肿性间质性肾炎和肾钙质沉着症（n = 2）、高钙血症导致的肾衰竭（n = 1）。
该系列研究强调，在结节病患者的初始评估和随访期间均应系统地进行肾功能检查。
