microRNAs 与胆固醇代谢。
microRNAs and cholesterol metabolism.
机构信息
Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.
出版信息
Trends Endocrinol Metab. 2010 Dec;21(12):699-706. doi: 10.1016/j.tem.2010.08.008. Epub 2010 Sep 27.
Cholesterol metabolism is tightly regulated at the cellular level. In addition to classic transcriptional regulation of cholesterol metabolism (e.g. by SREBP and LXR), members of a class of non-coding RNAs termed microRNAs (miRNAs) have recently been identified to be potent post-transcriptional regulators of lipid metabolism genes, including cholesterol homeostasis. We and others have recently shown that miR-33 regulates cholesterol efflux and HDL biogenesis by downregulating the expression of the ABC transporters, ABCA1 and ABCG1. In addition to miR-33, miR-122 and miR-370 have been shown to play important roles in regulating cholesterol and fatty acid metabolism. These new data suggest important roles of microRNAs in the epigenetic regulation of cholesterol metabolism and have opened new avenues for the treatment of dyslipidemias.
胆固醇代谢在细胞水平受到严格调控。除了胆固醇代谢的经典转录调控（例如通过 SREBP 和 LXR）外，最近还发现一类称为 microRNAs (miRNAs) 的非编码 RNA 成员是脂质代谢基因（包括胆固醇稳态）的有效转录后调节剂。我们和其他人最近表明，miR-33 通过下调 ABC 转运蛋白 ABCA1 和 ABCG1 的表达来调节胆固醇外排和 HDL 生成。除了 miR-33 外，miR-122 和 miR-370 也被证明在调节胆固醇和脂肪酸代谢方面发挥重要作用。这些新数据表明 microRNAs 在胆固醇代谢的表观遗传调控中发挥重要作用，并为治疗血脂异常开辟了新途径。
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