微小RNA和长链非编码RNA：子宫内膜异位症潜在的非侵入性生物标志物
miRNAs and lncRNAs: Potential Non-Invasive Biomarkers for Endometriosis.
作者信息
Maier Ioana Maria, Maier Adrian Cornel
机构信息
Emergency Military Hospital, 800150 Galati, Romania.
Faculty of Medicine and Pharmacy, Dunarea de Jos University, 800008 Galati, Romania.
出版信息
Biomedicines. 2021 Nov 11;9(11):1662. doi: 10.3390/biomedicines9111662.
Abstract
Many studies have tried to understand the mechanism of endometriosis and its manner of manifestation. However, the only method of diagnosis considered as the gold standard in endometriosis is an invasive method called exploratory laparoscopy. Hence, there is a need to identify non-invasive or minimally invasive methods to minimize patients' suffering, thus increasing their addressability at the earliest possible staging of the disease, and to diagnose this condition as soon as possible. miRNAs (microRNAs) and lncRNAs (long-noncoding RNAs) are potential non-invasive diagnostic methods for endometriosis. Multiple clinical trials indicate that miRNA can be used as a non-invasive method in the diagnosis and differentiation of endometriosis stages.
摘要
许多研究试图了解子宫内膜异位症的发病机制及其表现方式。然而，被视为子宫内膜异位症诊断金标准的唯一方法是一种名为探索性腹腔镜检查的侵入性方法。因此，有必要确定非侵入性或微创方法，以尽量减少患者的痛苦，从而在疾病的最早阶段提高其可诊治性，并尽快诊断出这种疾病。微小RNA（miRNA）和长链非编码RNA（lncRNA）是子宫内膜异位症潜在的非侵入性诊断方法。多项临床试验表明，miRNA可作为一种非侵入性方法用于子宫内膜异位症的诊断和分期鉴别。
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