Heinrich-Heine-University Düsseldorf, Institute for Microbiology, Universitätsstr. 1/Bldg. 26.12, 40225 Düsseldorf, Germany.
Curr Opin Microbiol. 2010 Dec;13(6):693-9. doi: 10.1016/j.mib.2010.08.013. Epub 2010 Sep 27.
The corn pathogen Ustilago maydis relies on defined developmental programs to regulate morphological switches during the infection process. Research on RNA-binding proteins has demonstrated the substantial contribution of posttranscriptional control in regulating growth, morphology and pathogenicity. In particular, functional analysis of the two sequence-specific RNA-binding proteins Khd4 and Rrm4 revealed the importance of regulated mRNA stability and transport, respectively. For example, in infectious filaments microtubule-dependent transport of mRNAs encoding polarity factors is key in establishing the axis of polarity. These findings probably represent only a few of the emerging discoveries related to posttranscriptional control in filamentous fungi. Research progress may also prove informative compared to similar regulatory mechanisms in operation during developmental and neuronal processes in vertebrates.
玉米病原体 Ustilago maydis 依赖于明确的发育程序来调节感染过程中的形态转换。RNA 结合蛋白的研究表明，在后转录控制在调节生长、形态和致病性方面具有重要作用。特别是，对两个序列特异性 RNA 结合蛋白 Khd4 和 Rrm4 的功能分析分别揭示了调节 mRNA 稳定性和运输的重要性。例如，在感染性丝状体中，编码极性因子的 mRNAs 的微管依赖性运输对于建立极性轴至关重要。这些发现可能只是与丝状真菌中转录后控制相关的新兴发现中的一小部分。与脊椎动物发育和神经元过程中运作的类似调节机制相比，研究进展也可能具有信息性。
