柠檬汁给药后腮腺中放射性碘的放射性药物动力学。

Radiopharmacokinetics of radioiodine in the parotid glands after the administration of lemon juice.

机构信息

Division of Nuclear Medicine, Washington Hospital Center,110 Irving Street NW, Washington, DC 2001, USA.

出版信息

Thyroid. 2010 Oct;20(10):1113-9. doi: 10.1089/thy.2009.0429.

DOI:10.1089/thy.2009.0429

PMID:20883172

Abstract

BACKGROUND

The ability of sialagogues to increase or decrease radiation induced-sialoadenitis and/or xerostomia after therapeutic administration of ¹³¹I is controversial. To evaluate this we measured the radiopharmacokinetics of ¹²³I in the parotid glands (PGs) after its administration of lemon juice (LJ).

METHODS

A retrospective review was performed on all patients who had a salivary gland scan performed before ¹³¹I therapy between July 2008 and April 2009 at the Washington Hospital Center. Two hours after ¹²³I was given orally, dynamic scintigraphy was initiated. Five milliliters of LJ was given 5 minutes later. Then, the patient was imaged for 1 hour (phase 1) at which point the sequence was repeated (phase 2). Twenty-three patients were studied. For each PG, the presence or absence of uptake was assessed, and based on background corrected counts, the mean, range, and standard deviation were determined for multiple radiopharmacokinetic parameters such as (i) percent radioiodine washout, (ii) time from LJ administration to re-accumulation of radioiodine to pre-LJ activity, and (iii) percent reduction in radiation absorbed dose to the PGs if LJ had been re-administered at the time the radioiodine activity re-accumulated to the pre-LJ activity.

RESULTS

The mean ± one standard deviation and range for percent washout were 84% ± 18% (35%-100%) and 83% ± 21% (37%-100%) in phase 1 and 2, respectively. The times from LJ to re-accumulation of the radioiodine to the pre-LJ activity were 21 ± 10 minutes (4-45 minutes) and 40 ± 14 minutes (12-62 minutes) for phase 1 and 2, respectively. The estimated percent reduction in radiation absorbed dose to the PGs following the first and second administration of LJ was 37% ± 14% (13%-93%) and 47% ± 16% (21%-97%), respectively.

CONCLUSIONS

The washout of radioiodine from the PGs is rapid but transient. Early repeat administration may result in continued and cumulative reduction of radiation absorbed dose in the PGs.

摘要

背景

唾液刺激剂在放射性唾液腺炎和/或口干症的治疗中增加或减少 ¹³¹I 诱导的作用存在争议。为了评估这一点，我们测量了¹²³I 在柠檬汁（LJ）给药后在腮腺（PGs）中的放射性药代动力学。

方法

对 2008 年 7 月至 2009 年 4 月期间在华盛顿医院中心进行¹³¹I 治疗前进行唾液腺扫描的所有患者进行了回顾性审查。¹²³I 口服给药后 2 小时开始动态闪烁成像。5 分钟后给予 5 毫升 LJ。然后，患者在 1 小时内进行成像（第 1 阶段），此时重复该序列（第 2 阶段）。研究了 23 名患者。对于每个 PG，评估了摄取的存在或不存在，并根据背景校正后的计数，确定了多个放射性药代动力学参数的平均值、范围和标准差，例如：（i）放射性碘洗脱百分比，（ii）从 LJ 给药到放射性碘重新积聚到 LJ 前活性的时间，以及（iii）如果在放射性碘活动重新积聚到 LJ 前活性时重新给予 LJ，则 PG 吸收剂量的减少百分比。

结果

第 1 阶段和第 2 阶段的平均洗脱百分比分别为 84%±18%（35%-100%）和 83%±21%（37%-100%）。从 LJ 到放射性碘重新积聚到 LJ 前活性的时间分别为 21±10 分钟（4-45 分钟）和 40±14 分钟（12-62 分钟），用于第 1 阶段和第 2 阶段。第一次和第二次给予 LJ 后，PG 吸收剂量估计减少百分比分别为 37%±14%（13%-93%）和 47%±16%（21%-97%）。