纳米颗粒在血清蛋白存在下的细胞结合。
Cellular binding of nanoparticles in the presence of serum proteins.
机构信息
School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, Georgia 30332, USA.
出版信息
Chem Commun (Camb). 2011 Jan 7;47(1):466-8. doi: 10.1039/c0cc02618b. Epub 2010 Oct 1.
PMID:20886139
Abstract
Cellular binding of cationic nanoparticles in the presence of serum proteins was probed with two-colour fluorescence microscopy. Cationic nanoparticles associate with serum proteins in solution and bind to the cell surface as a single anionic complex. Displacement of serum proteins from the nanoparticles was found to be protein dependent.
摘要
采用双色荧光显微镜研究了在血清蛋白存在下阳离子纳米颗粒在细胞中的结合情况。阳离子纳米颗粒在溶液中与血清蛋白结合，并作为单一的阴离子复合物结合到细胞表面。研究发现，从纳米颗粒上置换血清蛋白是依赖于蛋白质的。
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