从凤仙花中分离得到的 2-甲氧基-1,4-萘醌，该植物是一个筛选抑制 Wnt 信号通路活性的项目中发现的。
2-methoxy-1,4-naphthoquinone isolated from Impatiens balsamina in a screening program for activity to inhibit Wnt signaling.
机构信息
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
出版信息
J Nat Med. 2011 Jan;65(1):234-6. doi: 10.1007/s11418-010-0471-0. Epub 2010 Oct 1.
A screening study using a luciferase assay to identify natural products which inhibit Wnt signaling was carried out. The bioassay-guided fractionation of aerial parts of a plant, Impatiens balsamina, led to the isolation of 2-methoxy-1,4-naphthoquinone (1) as an active compound. Compound 1 inhibited the TCF/β-catenin (TOP) transcriptional activity (IC(50) 2.9 µM), while it decreased the transcriptional activity of FOP (mutated TCF-binding site)-transfected cells at >5 µM.
采用萤光素酶 assay 进行了一项筛选研究，以鉴定抑制 Wnt 信号的天然产物。生物活性导向分离，从凤仙花属植物（Impatiens balsamina）的地上部分中分离得到 2-甲氧基-1,4-萘醌（1）作为活性化合物。化合物 1 抑制 TCF/β-catenin (TOP) 转录活性（IC(50) 2.9 μM），而在 >5 μM 时则降低了突变 TCF 结合位点（FOP）转染细胞的转录活性。
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