Addy M, Mostafa P, Newcombe R G
University of Wales College of Medicine, Cardiff.
Clin Prev Dent. 1990 Oct-Nov;12(4):28-33.
During a study to assess the efficacy of five toothpastes in the treatment of dentin hypersensitivity, the plaque scores of patients were recorded at baseline, 2, 4, and 6 weeks treatment and 6 weeks post-treatment visits. Baseline buccal and lingual plaque indexes were found comparable between the groups and the mean buccal plaque scores were considered low by normal standards. During the use of the three experimental silica-based pastes, one containing strontium acetate, one strontium acetate and MFP and a commercially available formaldehyde-containing paste, plaque scores fell significantly and to a similar extent in all four groups. After cessation of treatment at 6 weeks, plaque scores had increased back to baseline in all groups. During the use of a diatomaceous earth/strontium chloride toothpaste, commercially available, plaque scores increased significantly, both from baseline and by comparison with the other four pastes. Nevertheless, plaque scores in this group returned to baseline levels after cessation of treatment and a return to use of a conventional non-desensitizing toothpaste. The effects of all but the diatomaceous earth/strontium chloride toothpaste would not be inconsistent with previous experience in toothbrushing studies where patients are monitored regularly. The effects on plaque did not necessarily coincide with the previously reported treatment benefit of the respective products in dentin hypersensitivity.
在一项评估五种牙膏治疗牙本质过敏症疗效的研究中，记录了患者在基线、治疗2周、4周和6周以及治疗后6周复诊时的牙菌斑评分。发现各治疗组之间基线时的颊侧和舌侧牙菌斑指数相当，且按照正常标准，平均颊侧牙菌斑评分较低。在使用三种实验性二氧化硅基牙膏（一种含醋酸锶，一种含醋酸锶和MFP，以及一种市售含甲醛牙膏）期间，所有四组的牙菌斑评分均显著下降，且下降程度相似。在6周治疗结束后，所有组的牙菌斑评分均回升至基线水平。在使用一种市售的硅藻土/氯化锶牙膏期间，牙菌斑评分从基线开始显著增加，并且与其他四种牙膏相比也有所增加。然而，在停止使用该牙膏并恢复使用传统的非脱敏牙膏后，该组的牙菌斑评分恢复到了基线水平。除硅藻土/氯化锶牙膏外，其他牙膏的效果与之前刷牙研究中的经验一致，在这些研究中会定期对患者进行监测。对牙菌斑的影响不一定与之前报道的各产品在牙本质过敏症治疗中的益处相符。
