Docimo Raffaella, Perugia Cesare, Bartolino Martina, Maturo Paolo, Montesani Luigi, Zhang Yun Po, DeVizio William, Mateo Luis R, Dibart Serge
University of Rome at Tor Vergata, Rome, Italy.
J Clin Dent. 2011;22(4):121-7.
The objective of this eight-week, single-center, three-cell, double-blind, and randomized clinical study was to evaluate the dentin hypersensitivity reduction efficacy of three commercially available toothpastes: 1) Colgate Sensitive Pro-Relief Toothpaste (also marketed as elmex Sensitive Professional); 2) Sensodyne Rapid Relief Toothpaste; and (3) Crest Cavity Protection Toothpaste.
150 subjects, having two teeth with tactile and air blast hypersensitivity, were assigned to one of the three study groups (50/group). Subjects were then asked to brush their teeth for one minute, twice daily, with the given toothpaste. The dentin hypersensitivity and oral tissues were evaluated at baseline, two weeks, four weeks, and eight weeks. Comparison of the treatment groups with respect to gender was conducted using a chi-square analysis, and with respect to age and baseline hypersensitivity scores was performed using the analysis of variance (ANOVA). Within-treatment effects were analyzed using the paired t-test, while the analysis of covariance (ANCOVA) was used to examine between-treatment effects. The post hoc Tukey test was performed for pair-wise comparisons. All statistical tests were two-sided using a significance level of alpha = 0.05.
After two, four, and eight weeks of daily use of the products, all three groups showed a statistically significant reduction from baseline in tactile and air blast dentin hypersensitivity (p < 0.05). Colgate Sensitive Pro-Relief toothpaste produced a significant improvement in mean tactile and air blast dentin hypersensitivity scores, and was more effective than Sensodyne Rapid Relief toothpaste and Crest Cavity Protection toothpastes (p < 0.05).
Colgate Sensitive Pro-ReliefToothpaste, used twice daily, significantly reduces dentin hypersensitivity, and is significantly more effective in reducing dentin hypersensitivity than Sensodyne Rapid Relief Toothpaste and Crest Cavity Protection Toothpaste.
这项为期八周的单中心、三分组、双盲随机临床研究旨在评估三种市售牙膏降低牙本质过敏的效果：1）高露洁敏感专业修复牙膏（也以elmex敏感专业牙膏销售）；2）舒适达快速抗敏牙膏；3）佳洁士防蛀牙膏。
150名有两颗牙齿存在触觉和吹气过敏的受试者被分配到三个研究组之一（每组50人）。然后要求受试者每天用指定牙膏刷牙两次，每次一分钟。在基线、两周、四周和八周时评估牙本质过敏和口腔组织情况。使用卡方分析对治疗组的性别进行比较，使用方差分析（ANOVA）对年龄和基线过敏评分进行比较。使用配对t检验分析治疗内效应，使用协方差分析（ANCOVA）检验治疗间效应。进行事后Tukey检验进行两两比较。所有统计检验均为双侧检验，显著性水平α = 0.05。
在每天使用这些产品两周、四周和八周后，所有三组的触觉和吹气牙本质过敏与基线相比均有统计学显著降低（p < 0.05）。高露洁敏感专业修复牙膏在平均触觉和吹气牙本质过敏评分上有显著改善，且比舒适达快速抗敏牙膏和佳洁士防蛀牙膏更有效（p < 0.05）。
每天使用两次高露洁敏感专业修复牙膏可显著降低牙本质过敏，且在降低牙本质过敏方面比舒适达快速抗敏牙膏和佳洁士防蛀牙膏显著更有效。
