Department of Physiology, University of Tartu, Tartu, Estonia.
Behav Brain Res. 2011 Feb 2;217(1):21-31. doi: 10.1016/j.bbr.2010.09.019. Epub 2010 Oct 1.
In rodents, the Lsamp gene has been implicated in trait anxiety, fear reaction and fear conditioning. Human data link the LSAMP gene to several psychiatric disorders. In this study, we presented a general phenotypic characterization of Lsamp gene-deficient mouse line, created by deleting exon 1b. These mice displayed no gross sensory-motor deficiencies, no overt abnormalities and performed normally in memory and learning tests. However, they responded with increased activity to new environments. Moreover, they displayed reduced anxiety and notable deviations in social behaviour, such as lack of whisker trimming, reduced aggressiveness and reduced dominance. One possible explanation for the anxiolytic-like effect of the deletion of the Lsamp gene is a shift in balance in the Gabra1 and Gabra2 genes in the temporal lobe in favor of the Gabra2 transcript, encoding α2 subunit of GABA(A) receptors that mediate the stimulating effect of GABA agonists. The overall phenotype of Lsamp-deficient mice, characterized by decreased anxiety and several alterations in social behaviour, makes them a good model for studying the molecular mechanisms behind inadequate social behaviours observed in several psychiatric disorders.
在啮齿动物中，Lsamp 基因与特质焦虑、恐惧反应和恐惧条件作用有关。人类数据将 LSAMP 基因与几种精神疾病联系起来。在这项研究中，我们展示了一种由删除外显子 1b 而创建的 Lsamp 基因缺失小鼠系的一般表型特征。这些小鼠没有明显的感觉运动缺陷，没有明显的异常，并且在记忆和学习测试中表现正常。然而，它们对新环境的反应活动增加。此外，它们表现出焦虑减轻和明显的社交行为偏差，例如缺乏胡须修剪、攻击性降低和支配地位降低。Lsamp 基因缺失的抗焦虑样效应的一个可能解释是，颞叶中 Gabra1 和 Gabra2 基因的平衡向 Gabra2 转录本转移，该转录本编码 GABA(A)受体的 α2 亚基，GABA 激动剂的刺激作用通过该受体介导。Lsamp 缺陷小鼠的整体表型，表现为焦虑减轻和几种社交行为改变，使它们成为研究几种精神疾病中观察到的社交行为不足的分子机制的良好模型。
