体感觉神经元多样性的产生及其对感觉编码的影响。
Generation of somatic sensory neuron diversity and implications on sensory coding.
机构信息
Dana-Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA.
出版信息
Curr Opin Neurobiol. 2011 Feb;21(1):52-60. doi: 10.1016/j.conb.2010.09.003. Epub 2010 Oct 1.
Abstract
Neurons in the dorsal root ganglia (DRG) are composed of a variety of sensory modalities, three of which are pain-sensing nociceptors, temperature-sensing thermoceptors, and itch-sensing pruriceptors. All these neurons are emerged from a common pool of embryonic DRG neurons that are marked by the expression of the neurotrophin receptor TrkA. Here we discuss how intrinsic transcription factors interface with target-derived signals to specify these functionally distinct sensory neurons. We will also discuss how this control mechanism provides a developmental perspective for the coding of somatic sensations.
摘要
背根神经节（DRG）中的神经元由多种感觉模式组成，其中三种是痛觉感受器、温度感受器和痒觉感受器。所有这些神经元都来自于一个共同的胚胎 DRG 神经元库，这些神经元通过表达神经营养因子受体 TrkA 来标记。在这里，我们将讨论内在转录因子如何与靶源性信号相互作用来特化这些功能不同的感觉神经元。我们还将讨论这种控制机制如何为躯体感觉的编码提供一个发育的视角。
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