Institut Cochin, Université Paris Descartes, CNRS UMR8104, Paris, France.
Trends Endocrinol Metab. 2010 Nov;21(11):684-90. doi: 10.1016/j.tem.2010.08.009.
AT2, the second subtype of angiotensin II receptors, is a major component of the renin-angiotensin system involved in cardiovascular and neuronal functions. AT2 belongs to the superfamily of G protein-coupled receptors, but its intracellular signaling pathways have long remained elusive. Over the past few years, efforts to characterize this atypical receptor have led to the identification of novel molecular scaffolds that directly bind to its intracellular tail. The present review focuses on a family of AT2 receptor-interacting proteins (ATIPs) involved in neuronal differentiation, vascular remodeling and tumor suppression. Recent findings that ATIPs and ATIP-related proteins associate with microtubules suggest that they might constitute a novel family of multifunctional proteins regulating a wide range of physiopathological functions.
AT2，血管紧张素 II 受体的第二种亚型，是参与心血管和神经元功能的肾素-血管紧张素系统的主要组成部分。AT2 属于 G 蛋白偶联受体超家族，但长期以来，其细胞内信号通路一直难以捉摸。在过去的几年中，对这种非典型受体进行特征描述的努力导致了对直接与其细胞内尾部结合的新型分子支架的鉴定。本综述重点介绍了一组参与神经元分化、血管重塑和肿瘤抑制的 AT2 受体相互作用蛋白 (ATIP)。最近的发现表明，ATIP 和 ATIP 相关蛋白与微管相关，这表明它们可能构成一组新的多功能蛋白，调节广泛的生理病理功能。
