Csatlós Eva, Rigó János, Szabó István, Nagy Zsolt, Joó József Gábor
Semmelweis Egyetem, Általános Orvostudományi Kar I. Szülészeti és Nőgyógyászati Klinika Budapest Baross utca 27. 1088.
Orv Hetil. 2010 Oct 17;151(42):1734-41. doi: 10.1556/OH.2010.28977.
Uterine fibroids, benign tumors of the human uterus, are the most common indication for hysterectomy. They are clinically apparent in 20-25% of women and cause significant complaints, like prolonged and heavy menstruation, pelvic pressure or pain, sometimes reproductive dysfunction. Though surgery has been the mainstay of fibroid treatment, various minimally invasive procedures have been developed in addition to hysterectomy and abdominal myomectomy. Formation of new leiomyomas after these conservative therapies remains a substantial problem. Also drug-therapy methods are available, but the possible side-effects limit their long-term use. Authors attempt to give an overview of this common gynecological disease, yielding a new insight into the basic biology and genetics of fibroids, with the hope of new and effective methods of therapy in the future.
子宫肌瘤是人类子宫的良性肿瘤，是子宫切除术最常见的指征。它们在20%至25%的女性中临床表现明显，并引发严重不适，如经期延长和经量过多、盆腔压迫感或疼痛，有时还会导致生殖功能障碍。尽管手术一直是子宫肌瘤治疗的主要手段，但除子宫切除术和腹部肌瘤切除术外，还开发了各种微创手术。这些保守治疗后新肌瘤的形成仍然是一个重大问题。药物治疗方法也有，但可能的副作用限制了它们的长期使用。作者试图对这种常见的妇科疾病进行概述，对肌瘤的基础生物学和遗传学有新的认识，希望未来能有新的有效治疗方法。
