Department of Neurology, University of Virginia Health System, Charlottesville, VA, USA.
Cleve Clin J Med. 2010 Oct;77(10):689-704. doi: 10.3949/ccjm.77gr.2010.
Autosomal dominant (early-onset) Alzheimer disease and the much more common sporadic Alzheimer disease share a common pathology but not necessarily a common pathophysiology. Common cardiovascular comorbidities are associated with increased risk for Alzheimer disease and offer opportunities for intervention. Class I evidence for prevention is extremely limited. The overall body of evidence suggests the best time to intervene is in midlife, not in old age.
常染色体显性（早发型）阿尔茨海默病和更为常见的散发性阿尔茨海默病具有共同的病理学特征，但不一定具有共同的病理生理学特征。常见的心血管合并症与阿尔茨海默病的风险增加相关，并提供了干预的机会。预防的 I 级证据极为有限。总体证据表明，干预的最佳时间是中年，而不是老年。
