Department of Rehabilitation Medicine, Seoul National University, College of Medicine, Seoul, Korea.
J Korean Med Sci. 2010 Oct;25(10):1499-505. doi: 10.3346/jkms.2010.25.10.1499. Epub 2010 Sep 20.
Transcranial direct current stimulation (tDCS) is associated with enhancement or weakening of the NMDA receptor activity and change of the cortical blood flow. Therefore, repeated tDCS of the brain with cerebrovascular injury will induce the functional and histologic changes. Sixty-one Sprague-Dawley rats with cerebrovascular injury were used. Twenty rats died during the experimental course. The 41 rats that survived were allocated to the exercise group, the anodal stimulation group, the cathodal stimulation group, or the control group according to the initial motor function. Two-week treatment schedules started from 2 days postoperatively. Garcia, modified foot fault, and rota-rod performance scores were checked at 2, 9, and 16 days postoperatively. After the experiments, rats were sacrificed for the evaluation of histologic changes (changes of the white matter axon and infarct volume). The anodal stimulation and exercise groups showed improvement of Garcia's and modified foot fault scores at 16 days postoperatively. No significant change of the infarct volume happened after exercise and tDCS. Neuronal axons at the internal capsule of infarct hemispheres showed better preserved axons in the anodal stimulation group. From these results, repeated tDCS might have a neuroprotective effect on neuronal axons in rat stroke model.
经颅直流电刺激（tDCS）与 NMDA 受体活性的增强或减弱以及皮质血流的变化有关。因此，脑血管损伤后的大脑重复 tDCS 将引起功能和组织学变化。使用 61 只患有脑血管损伤的 Sprague-Dawley 大鼠。在实验过程中有 20 只大鼠死亡。根据初始运动功能，41 只幸存大鼠被分配到运动组、阳极刺激组、阴极刺激组或对照组。从术后 2 天开始，为期 2 周的治疗方案。术后 2、9 和 16 天分别检查 Garcia、改良足失误和转棒性能评分。实验结束后，处死大鼠评估组织学变化（白质轴突变化和梗死体积）。术后 16 天，阳极刺激和运动组的 Garcia 和改良足失误评分均有所改善。运动和 tDCS 后梗死体积无明显变化。梗死半球内囊的神经元轴突在阳极刺激组中显示出更好的轴突保留。从这些结果来看，重复 tDCS 可能对大鼠中风模型中的神经元轴突具有神经保护作用。
