肾上腺-尾状核移植对帕金森病患者脑脊液中硫酸猪毛菜酚水平的影响。

Effect of adrenal-caudate transplantation on CSF levels of salsolinol sulfate in patients with Parkinson's disease.

作者信息

Faraj B A, Camp V M, Watts R L

机构信息

Department of Radiology (Division of Nuclear Medicine), Emory University School of Medicine, Atlanta, Georgia.

出版信息

J Neural Transm Suppl. 1990;32:481-4. doi: 10.1007/978-3-7091-9113-2_65.

DOI:10.1007/978-3-7091-9113-2_65

PMID:2089111

Abstract

The main objective of this study was to determine whether the activation of dopaminergic pathways through adrenal-caudate transplantation stimulates the production of the dopamine cyclic metabolite salsolinol in CSF of patients with Parkinson's disease. Salsolinol sulfate in CSF samples was assayed by radioenzymatic technique. The outcome of this study revealed that the replacement of degenerative nigrostriatal neurons with new dopamine-producing cells by adrenal brain transplants resulted in significant increase in CSF concentration of salsolinol sulfate as compared to preoperative levels.

摘要

本研究的主要目的是确定通过肾上腺-尾状核移植激活多巴胺能通路是否会刺激帕金森病患者脑脊液中多巴胺环化代谢产物萨索利诺的产生。采用放射酶法测定脑脊液样本中的硫酸萨索利诺。该研究结果表明，与术前水平相比，肾上腺脑移植用新的多巴胺生成细胞替代退行性黑质纹状体神经元后，脑脊液中硫酸萨索利诺的浓度显著增加。