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依托泊苷与异环磷酰胺治疗对美法仑和泼尼松(MP)及长春新碱、阿霉素和地塞米松(VAD)耐药的浆细胞骨髓瘤:一例报告

Etoposide and ifosfamide for MP (melphalan and prednisolone)- and VAD (vincristine, adriamycin and dexamethasone)-resistant plasma cell myeloma: a case report.

作者信息

Ikeda K, Abe N, Morioka A, Inoo M, Nagai M, Kubota Y, Irino S

机构信息

First Department of Internal Medicine, Kagawa Medical School, Japan.

出版信息

Jpn J Med. 1990 Sep-Oct;29(5):516-8. doi: 10.2169/internalmedicine1962.29.516.

Abstract

A patient with plasma cell myeloma refractory to both MP (melphalan-prednisolone) and VAD (vincristine-adriamycin-dexamethasone) was treated with a combination chemotherapy consisting of VP-16, ifosfamide and dexamethasone (VID). A partial remission of 12-month duration was achieved. VID combination might be considered for myeloma patients who are refractory to both MP and VAD, and not eligible for high-dose melphalan with bone marrow transplantation.

摘要

一名对MP(美法仑-泼尼松)和VAD(长春新碱-阿霉素-地塞米松)均耐药的浆细胞骨髓瘤患者接受了由VP-16、异环磷酰胺和地塞米松(VID)组成的联合化疗。获得了持续12个月的部分缓解。对于对MP和VAD均耐药且不符合大剂量美法仑联合骨髓移植条件的骨髓瘤患者,可考虑使用VID联合方案。

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