采用长春新碱、阿霉素、地塞米松联合方案（VAD）及美法仑、泼尼松龙联合方案（MP），随后使用α干扰素成功治疗IgE浆细胞白血病。
IgE plasma cell leukemia successfully treated with combination VAD (vincristine, doxorubicin, dexamethasone) and MP (melphalan, prednisolone) followed by interferon-alpha.
作者信息
Yamagata N, Shimazaki C, Goto H, Hirata T, Ashihara E, Oku N, Inaba T, Fujita N, Nakagawa M
机构信息
Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
出版信息
Am J Hematol. 1994 Mar;45(3):262-4. doi: 10.1002/ajh.2830450315.
A 69-year-old woman with IgE/kappa plasma cell leukemia (PCL) was treated with a sequential combination of VAD (vincristine, doxorubicin, dexamethasone) and MP (melphalan, prednisolone) followed by interferon-alpha (IFN alpha). A complete remission was achieved for 14 months. Maintenance therapy with IFN alpha has continued for an additional 10 months. IgE PCL is extremely rare. The biological characteristics of the myeloma cells, including surface marker, adhesion molecule, karyotype, DNA analysis, and the response to various cytokines, are presented.
一名69岁的患有免疫球蛋白E/κ型浆细胞白血病（PCL）的女性患者，先后接受了VAD（长春新碱、阿霉素、地塞米松）和MP（美法仑、泼尼松龙）联合治疗，随后使用α干扰素（IFNα）进行治疗。患者获得了14个月的完全缓解。使用IFNα的维持治疗又持续了10个月。免疫球蛋白E型PCL极为罕见。本文介绍了骨髓瘤细胞的生物学特性，包括表面标志物、黏附分子、核型、DNA分析以及对各种细胞因子的反应。
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