Topçu S, Dökmetaş I, Yalçin N
Cumhuriyet Universitesi, Tip Fakültesi, Iç Hastahklari Anabilim Dah.
Mikrobiyol Bul. 1990 Apr;24(2):111-9.
The clinical and laboratory findings, and the results of treatment of 16 Meningococcal meningitis cases, who were hospitalized, are investigated, and discussed with the literature. On application all of the patients had headache, meningeal irritation findings, and fever (% 75), nausea and vomiting (% 62.5), rash (% 56.25), unconsciousness (% 50), coma state (% 31.25), Herpes labialis (% 31.25), affecting of cranial nerves (% 12.5), arthritis (% 12.5), and carditis (% 6.25). At the peripheric blood examinations, all had leucocytosis, and neutrophilia. In the direct examination of the cerebrospinal-fluid, in 15 patients gram negative diplococci were seen, and in 11 patients the microorganisms grew on culture. The patients were given Crystalized-Penicillin in doses of 20-30 million IU/day. In the two cases some complications, resistance, and allergy developed, so the treatment changed. Only a patient died, and in the other cases no relapse and sequel were seen.
对16例住院的脑膜炎球菌性脑膜炎病例的临床和实验室检查结果以及治疗结果进行了调查,并与文献进行了讨论。所有患者就诊时均有头痛、脑膜刺激征,发热(75%)、恶心呕吐(62.5%)、皮疹(56.25%)、意识不清(50%)、昏迷状态(31.25%)、唇疱疹(31.25%)、颅神经受累(12.5%)、关节炎(12.5%)和心肌炎(6.25%)。外周血检查时,所有患者均有白细胞增多和中性粒细胞增多。脑脊液直接检查中,15例患者可见革兰阴性双球菌,11例患者培养出微生物。患者接受了剂量为每日2000 - 3000万IU的结晶青霉素治疗。有2例出现了一些并发症、耐药和过敏情况,因此改变了治疗方案。仅1例患者死亡,其他病例未见复发和后遗症。