[青霉素在儿童脑膜炎球菌性脑膜炎中的药理学评估]
[Pharmacologic evaluation of penicillin in children with meningococcal meningitis].
作者信息
Ribes C, Cambra J, Asensi F, Otero M C, Cantón E
出版信息
An Esp Pediatr. 1983 Jan;18(1):5-9.
PMID:6870077
Abstract
Levels of penicillin both in blood and CSF are determined in 11 children with meningococcal meningitis. Authors compare these values with MIC. The therapeutic pattern was 500.000 Ul/Kg/day of benzylpenicillin, in six doses, with a single initial doses of 200.000 Ul/Kg. The results recommend not to use a lower doses in order to assure a permanently efficient penicillin concentration.
摘要
对11例患脑膜炎球菌性脑膜炎的儿童测定了其血液和脑脊液中的青霉素水平。作者将这些值与最低抑菌浓度进行了比较。治疗方案为每日500,000单位/千克的苄青霉素，分六次给药，单次初始剂量为200,000单位/千克。结果表明，为确保青霉素浓度始终有效，不应使用更低剂量。
相似文献
1
[Pharmacologic evaluation of penicillin in children with meningococcal meningitis].[青霉素在儿童脑膜炎球菌性脑膜炎中的药理学评估]
An Esp Pediatr. 1983 Jan;18(1):5-9.
2
3
4
A pharmacologic evaluation of penicillin in children with purulent meningitis.
N Engl J Med. 1977 Aug 25;297(8):410-3. doi: 10.1056/NEJM197708252970802.
5
[Failure of the treatment with penicillin in a case of Neisseria meningitidis meningitis].[1例脑膜炎奈瑟菌脑膜炎青霉素治疗失败的情况]
Medicina (B Aires). 1994;54(5 Pt 1):427-30.
6
7
Treatment of meningococcal meningitis in children in Khartoum.喀土穆儿童脑膜炎球菌性脑膜炎的治疗
Indian Pediatr. 1975 May;12(5):387-91.
8
Four days of penicillin therapy for meningococcal meningitis.
Arch Intern Med. 1986 Dec;146(12):2380-2.
9
[Dexamethasone in the treatment of meningococcal meningitis].[地塞米松治疗脑膜炎球菌性脑膜炎]
Rev Paul Med. 1986 Mar-Apr;104(2):61-5.
10
[Therapeutic failure of ampicillin during meningococcal meningitis].[氨苄西林治疗脑膜炎球菌性脑膜炎的治疗失败]
Ann Pediatr (Paris). 1976 Nov 2;23(11):695-7.
Zotero 插件