中枢神经系统药物的构效关系研究。第1部分：某些1,2,3,4-四氢-β-咔啉急性毒性和镇静作用的Free-Wilson分析
Structure-activity relationship studies of CNS agents. Part 1: The Free-Wilson analysis of acute toxicity and sedative effect of some 1,2,3,4-tetrahydro-beta-carbolines.
作者信息
Mokrosz J L, Dukat M, Misztal S, Chojnacka-Wójcik E, Tatarczyńska E
机构信息
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
出版信息
Pharmazie. 1990 Oct;45(10):765-7.
PMID:2089388
Abstract
It has been found that 3-alkoxycarbonyl-beta-carbolines are almost non-toxic and showed a sedative effect. The quantitative relationship between the structure of some 1,2,3,4-tetrahydro-beta-carbolines and their acute toxicity and sedative effect was found using the Free-Wilson approach.
摘要
已发现3-烷氧羰基-β-咔啉几乎无毒，并具有镇静作用。使用Free-Wilson方法发现了一些1,2,3,4-四氢-β-咔啉的结构与其急性毒性和镇静作用之间的定量关系。
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