Synthesis and pharmacological properties of decahydro-5H-pyrido [1',2';5,1] imidazo [3,4-a]-beta-carbolines. Part II.
作者信息
Misztal S, Dukat M, Chojnacka-Wójcik E, Tatarczyńska E
机构信息
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
出版信息
Pol J Pharmacol Pharm. 1988 Jul-Aug;40(4):429-33.
PMID:3222182
Abstract
Ten cyclic animals (1-10), including a form of decahydro-5H-pyrido [1',2';5,1] imidazo [3,4-a]-beta-carboline, were obtained by treating erythro 1-(2'-piperidyl)-1,2,3,4-tetrahydro-beta-carboline with aldehydes. The anticonvulsant action of those compounds (1-10) was investigated in mice using a behavioral test. Only 5-(3-chlorophenyl) (2) and 5-(3-pyridyl) (9) derivatives showed an anticonvulsant activity in the electric seizure test, but their therapeutic index was inferior to that of phenytoin.
摘要
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