Goertchen R, Schiche I, Modelmog D, Kunze K
Institut für Pathologie, Bakteriologie und Serologie, des Bezirkskrankenhauses Görlitz, BRD.
Zentralbl Allg Pathol. 1990;136(7-8):663-70.
This study had been conducted for the purpose of obtaining information on incidence and biological significance of metaplasia and dysplasia of the urinary bladder. Therefore, postmortem investigations were made of 1,117 urinary bladders, using optical light microscopy and mapping. They were related to a medium-size industrial town with an autopsy frequency of 98%. Metaplasia (58%) and dysplasia (13%) are no rare urinary bladder findings and occur particularly to individuals in somewhat advanced age, with no significant sex-related difference. Urocystitis was recorded from over 50% of all cases reviewed. More strongly pronounced inflammatory processes appeared to be risk factors for higher severity of dysplasia. Inconspicuous as well as metaplastic von Brunn's nests or squamous and glandular metaplasia without atypical cells should not be considered precarcinomas. However, atypical cells in terms of dysplasia were recordable from a small number of these metaplasias. Precancerous importance might be attributed to few of them, particularly in male patients with dysplastic squamous cell metaplasia. No reliable information, however, was available on premature development of dysplasia in lower age groups which would have meant a long-drawn process of carcinogenesis.
本研究旨在获取有关膀胱化生和发育异常的发生率及生物学意义的信息。因此，使用光学显微镜和绘图法对1117个膀胱进行了尸检调查。这些膀胱来自一个中等规模的工业城镇，尸检频率为98%。化生（58%）和发育异常（13%）在膀胱中并非罕见的发现，尤其在年龄稍大的个体中出现，且无明显的性别差异。在所有审查病例中，超过50%记录有膀胱炎。更明显的炎症过程似乎是发育异常严重程度较高的危险因素。不明显的以及化生的布伦巢或无非典型细胞的鳞状和腺性化生不应被视为癌前病变。然而，在少数这些化生中可记录到发育异常方面的非典型细胞。其中少数可能具有癌前重要性，尤其是在患有发育异常鳞状细胞化生的男性患者中。然而，关于较低年龄组发育异常的过早发生（这意味着漫长的致癌过程），尚无可靠信息。
