Martin H, Janda J, Behrbohm H
Institut für Pathologische Anatomie, Bereichs Medizin (Charité), Humboldt-Universität zu Berlin.
Zentralbl Allg Pathol. 1990;136(7-8):703-6.
Reported is a nasal oncocytoma with locally invasive properties in a 86 year old man. The tumor was histologically found to consist of cells rich in cytoplasm, with striking eosinophilia, granularity, and predominance of glandular architecture. Electron microscopy revealed typical oncocytes with abundant mitochondria in the cytoplasm, with many of them compressing the nuclei of tumor cells. The tumor reported was distinguished from unambiguously benign oncocytomas by its mitotic activity and locally invasive character. These properties should be noted in histologic diagnosis. Locally delimited but radical tumor removal is the adequate therapy.
报告了一例86岁男性的具有局部侵袭性的鼻腔嗜酸性细胞瘤。组织学检查发现肿瘤由富含细胞质的细胞组成,具有显著的嗜酸性、颗粒状以及腺性结构为主。电子显微镜显示典型的嗜酸性细胞,其细胞质中有丰富的线粒体,其中许多线粒体压迫肿瘤细胞的细胞核。所报告的肿瘤因其有丝分裂活性和局部侵袭性特征而与明确良性的嗜酸性细胞瘤不同。在组织学诊断中应注意这些特征。局部界定但彻底的肿瘤切除是合适的治疗方法。