Yamane K, Shima T, Okada Y, Takeda T, Uozumi T
Department of Neurosurgery, Chugoku Rousai Hospital, Kure, Japan.
Acta Neurochir Suppl (Wien). 1990;51:223-5. doi: 10.1007/978-3-7091-9115-6_75.
A rat embolization model was produced by occlusion of the main cerebral artery with a silicone cylinder embolus. Intracranial pressure was monitored by changes in epidural pressure (EDP), which was recorded by our designed flaccid microballoon. EDP changes could be divided into the two types: the first was moderate elevation, less than 20 mm Hg and the second was prominent, more than 20 mm Hg. Brain tissue pH on the embolized side showed heterogeneous changes composed of acidotic and alkalotic areas. Alkalotic change was frequently seen at the deep cerebrum which might be the result of plasma exudation due to disruption of blood-brain barrier (BBB). The degree of the EDP elevation was positively correlated with the extension of alkalotic area. Energy metabolism was also mainly disturbed in the deep cerebrum, but did not completely correspond to the pH change of the area. These results would indicate that embolization of the main cerebral artery could induce severe ischaemic insult on the deep cerebrum with massive brain swelling due to an early disruption of BBB.
通过用硅胶圆柱栓子阻塞大脑主要动脉建立大鼠栓塞模型。通过硬膜外压力（EDP）的变化监测颅内压，EDP由我们设计的松弛微球囊记录。EDP变化可分为两种类型：第一种是中度升高，小于20 mmHg，第二种是显著升高，大于20 mmHg。栓塞侧脑组织pH值呈现由酸中毒和碱中毒区域组成的异质性变化。碱中毒变化常见于大脑深部，这可能是血脑屏障（BBB）破坏导致血浆渗出的结果。EDP升高程度与碱中毒区域的范围呈正相关。能量代谢也主要在大脑深部受到干扰，但与该区域的pH变化并不完全对应。这些结果表明，大脑主要动脉的栓塞可导致大脑深部严重缺血性损伤，并因BBB早期破坏而出现大量脑肿胀。
