用前列环素类似物TTC-909进行缺血后治疗可减轻缺血性脑损伤。
Post-ischaemic treatment with the prostacycline analogue TTC-909 reduces ischaemic brain injury.
作者信息
Shima K, Ohashi K, Umezawa H, Chigasaki H, Karasawa Y, Okuyama S, Araki H, Otomo S
机构信息
Department of Neurosurgery, National Defense Medical College, Saitama, Japan.
出版信息
Acta Neurochir Suppl (Wien). 1990;51:242-4. doi: 10.1007/978-3-7091-9115-6_81.
The effects of stable PGI analogue TTC-909 on CBF and glucose metabolism was studied in the chronic stage of cerebral ischaemia produced by occluding the distal MCA in SHRSP. Administration of TTC-909 (100 ng/kg/day during 7 days) prevented the development of ischaemic oedema and improved secondary metabolic derangement coupled to flow in postischaemic tissues, particularly in the ischaemic rim.
在自发性高血压大鼠（SHRSP）中，通过闭塞大脑中动脉远端制造脑缺血慢性期，研究了稳定的前列环素类似物TTC-909对脑血流量（CBF）和葡萄糖代谢的影响。给予TTC-909（7天内每天100纳克/千克）可预防缺血性水肿的发展，并改善缺血后组织中与血流相关的继发性代谢紊乱，尤其是在缺血边缘。
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