急性颈上神经节切除术对易患中风的自发性高血压大鼠脑缺血后脑血流量和代谢的影响。

Effects of acute superior cervical ganglionectomy on cerebral blood flow and metabolism in stroke-prone spontaneously hypertensive rats subjected to cerebral ischaemia.

Nagao T, Sadoshima S, Ishitsuka T, Kusuda K, Shiokawa O, Ibayashi S, Fujishima M

Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Clin Exp Pharmacol Physiol. 1992 Jul;19(7):489-93. doi: 10.1111/j.1440-1681.1992.tb00494.x.

Abstract

The effects of acute bilateral superior cervical ganglionectomy on cerebral blood flow and metabolism were investigated in stroke-prone spontaneously hypertensive rats (SHRsp), before and during cerebral ischaemia. 2. The resting cerebral blood flow was comparable between the control and denervated animals. 3. There was no significant difference in cerebral blood flow or concentration of tissue energy metabolites (adenosine triphosphate [ATP], lactate and pyruvate) between the sham-operated control and denervated animals during ischaemia. 4. The results suggest that sympathetic innervation of cerebral vessels originating from superior cervical ganglia may not play a major role in the progression of cerebral ischaemia in SHRsp.

摘要

在易中风自发性高血压大鼠（SHRsp）脑缺血之前及期间，研究了急性双侧颈上神经节切除术对脑血流和代谢的影响。2. 对照组和去神经支配动物的静息脑血流相当。3. 在缺血期间，假手术对照组和去神经支配动物之间的脑血流或组织能量代谢物（三磷酸腺苷[ATP]、乳酸和丙酮酸）浓度无显著差异。4. 结果表明，源自颈上神经节的脑血管交感神经支配可能在SHRsp脑缺血进展中不发挥主要作用。