多胺蓄积与中枢神经系统（CNS）晚期迟发性放射性损伤发生过程中的血管源性水肿

Polyamine accumulation and vasogenic oedema in the genesis of late delayed radiation injury of the central nervous system (CNS).

作者信息

Gutin P H, McDermott M W, Ross G, Chan P H, Chen S F, Levin K J, Babuna O, Marton L J

机构信息

Brain Tumour Research Center, University of California, San Francisco.

出版信息

Acta Neurochir Suppl (Wien). 1990;51:372-4. doi: 10.1007/978-3-7091-9115-6_125.

DOI:10.1007/978-3-7091-9115-6_125

PMID:2089943

Abstract

Polyamine (PA) accumulation has been associated with blood-brain barrier (BBB) disruption and vasogenic oedema after cold injury. PAs and water content were measured in a rat spinal cord model of late-delayed radiation injury and were found to be elevated at paralysis. The elevated PA levels could be significantly reduced by treatment with difluoromethylornithine (DFMO). In unirradiated rats DFMO reduced putrescine to undetectable levels after 10-12 weeks. These data suggest that blockade of PA synthesis may be useful in treating the vasogenic oedema of radiation injury and may improve CNS radiation tolerance.

摘要

多胺（PA）蓄积与冷损伤后的血脑屏障（BBB）破坏和血管源性水肿有关。在大鼠晚期延迟性辐射损伤脊髓模型中测量了多胺和水分含量，发现它们在瘫痪时升高。用二氟甲基鸟氨酸（DFMO）治疗可显著降低升高的多胺水平。在未受辐射的大鼠中，DFMO在10 - 12周后将腐胺降低到无法检测的水平。这些数据表明，阻断多胺合成可能有助于治疗辐射损伤的血管源性水肿，并可能提高中枢神经系统的辐射耐受性。