Wang R, Ehara K, Tamaki N
Department of Neurosurgery, Kobe University, Japan.
Surg Neurol. 1993 May;39(5):348-54. doi: 10.1016/0090-3019(93)90198-a.
A spinal cord edema model was developed in the rat by inflicting a freezing injury at -40 degrees C for 3 minutes. Regional spinal cord blood flow, tissue water content, and histology were examined. White matter edema had extended several segments by 8 hours after the injury. Tissue water content increased by 20.6% at 24 hours. Spinal cord blood flow in surrounding tissues decreased by more than 25% 4 hours after the injury. The progression of spinal cord edema following freezing injury appeared to be due to disruption of the blood-spinal cord barrier.
通过在-40℃下造成3分钟的冷冻损伤，在大鼠中建立脊髓水肿模型。检测局部脊髓血流、组织含水量和组织学。损伤后8小时，白质水肿已扩展至几个节段。24小时时组织含水量增加了20.6%。损伤后4小时，周围组织的脊髓血流减少超过25%。冷冻损伤后脊髓水肿的进展似乎是由于血脊髓屏障的破坏。
