Rinaldi A, Mangiola A, Anile C, Maira G, Amante P, Ferraresi A
Institute of Neurosurgery, Rome, Italy.
Acta Neurochir Suppl (Wien). 1990;51:394-6. doi: 10.1007/978-3-7091-9115-6_132.
An experimental model of cold induced brain oedema was carried out in 7 albino rabbits by topic application of fluid N2 on the skull to examine the favourable effects of an appropriate tailored craniodural opening both on the whole brain perfusion and on the local dynamics of the oedematous fluid. After positioning the animals in a stereotactic frame the following parameters were recorded: ICP, carotid blood pressure and flow velocity, EEG, EKG. Histological staining with Evan's blue was utilized to check fluid extravasation. In all the animals the lesion was followed both by an ICP increase and a reduction in the carotid blood flow velocity so indicating an increase in the cerebrovascular resistances. In 4 animals the removal of the craniodural flap over the lesion dramatically reduced the ICP values and normalized the blood flow velocity. No difference in the Evan's blue distribution was noticed between the two groups of animals.
通过在7只白化兔的颅骨上局部应用液氮建立冷诱导脑水肿的实验模型，以研究适当的颅骨硬膜开口对全脑灌注和水肿液局部动力学的有利影响。将动物置于立体定向框架中后，记录以下参数：颅内压（ICP）、颈动脉血压和血流速度、脑电图（EEG）、心电图（EKG）。使用伊文思蓝进行组织学染色以检查液体外渗情况。在所有动物中，病变均导致颅内压升高和颈动脉血流速度降低，表明脑血管阻力增加。在4只动物中，切除病变上方的颅骨硬膜瓣显著降低了颅内压值并使血流速度恢复正常。两组动物之间伊文思蓝分布没有差异。
