Czernicki Z, Walecki J
Department of Neurosurgery, Polish Academy of Sciences, Warsaw.
Acta Neurochir Suppl (Wien). 1990;51:407-8. doi: 10.1007/978-3-7091-9115-6_136.
Using the cold lesion model vasogenic oedema was produced in 8 cats. The intracranial volume reserve was evaluated applying CT image numerical analysis (CTINA). Summarizing all voxels corresponding to CSF and brain tissue in 8 CT slices, the brain/CSF ratio was computed. The animals were studied at different time intervals after the lesion (2 h, 4 h, 6 h) then sacrificed and the spreading of oedema was estimated based on the BBB disturbances. The brain/CSF ratios varied from mean value of 0.043 in control animals to mean values of 0.022 in animals 6 hours after the lesion. The CTINA method was found very useful as a noninvasive screening method to study brain oedema development with a promising application in clinical practice.
使用冷损伤模型在8只猫身上诱发血管源性水肿。应用CT图像数值分析（CTINA）评估颅内容量储备。汇总8个CT切片中对应于脑脊液和脑组织的所有体素，计算脑/脑脊液比值。在损伤后的不同时间间隔（2小时、4小时、6小时）对动物进行研究，然后处死动物，并根据血脑屏障的破坏情况估计水肿的扩散。脑/脑脊液比值从对照动物的平均值0.043变化到损伤后6小时动物的平均值0.022。发现CTINA方法作为一种无创筛查方法，对于研究脑水肿的发展非常有用，在临床实践中有广阔的应用前景。
