Kuchiwaki H, Inao S, Woh T, Nagasaka M, Sugita K, Hanaichi T
Department of Neurosurgery Nagoya University School of Medicine, Japan.
Acta Neurochir Suppl (Wien). 1990;51:82-3. doi: 10.1007/978-3-7091-9115-6_28.
An ultrastructural study of adult mongrel dogs and cats was made to evaluate the changes in the microcirculation during cerebral oedema formation. Two to five cold injuries were made in one hemisphere in dogs and one lesion was made in cats. In several dogs arterial hypertension was induced with a balloon in the aorta. Intracranial pressure (ICP) and water content were measured. The specimens from the oedematous region were studied with transmission electron microscopy (TEM) and electron probe x-ray micro-analysis (EPMA). The TEM data showed swelling of the endothelium and astrocytic foot processes, enlarged perivascular spaces and increased number of endothelial vesicles. The EPMA findings indicated increases in Fe and Ca content in the perivascular spaces. In some cases, the amount of chloride in red cells was increased. The altered distributions of these metals suggested tissue injury and impairment of red cell and vessel wall functions.
对成年杂种犬和猫进行了超微结构研究，以评估脑水肿形成过程中微循环的变化。在犬的一个半球制造两到五个冷损伤，在猫制造一个损伤。在几只犬中，用主动脉内气囊诱导动脉高血压。测量颅内压（ICP）和含水量。用透射电子显微镜（TEM）和电子探针X射线微分析（EPMA）研究水肿区域的标本。TEM数据显示内皮细胞和星形胶质细胞足突肿胀、血管周围间隙扩大以及内皮小泡数量增加。EPMA结果表明血管周围间隙中铁和钙含量增加。在某些情况下，红细胞中的氯含量增加。这些金属分布的改变提示组织损伤以及红细胞和血管壁功能受损。
