Naruse H, Tanaka K, Nishimura S, Fugimoto K
Department of Neurosurgery, Osaka City University Medical School, Japan.
Acta Neurochir Suppl (Wien). 1990;51:87-9. doi: 10.1007/978-3-7091-9115-6_30.
The infusion model was used to investigate the resolution mechanism of vasogenic brain oedema. HRP dissolved in autoserum was infused into the white matter of cats. The infused protein in the oedema fluid seemed not only to be absorbed by pinocytosis or phagocytosis, as has been reported previously, but also to be quickly washed out via the perivascular space of the post-capillary venules. Smaller molecules such as HRP moved faster than serum albumin in these spaces after the infusion pump was turned off. Rapid flow of extracellular fluid via the perivascular space may play an important role on the resolution process of vasogenic brain oedema by accelerating diffusion.
采用灌注模型研究血管源性脑水肿的消退机制。将溶解于自体血清中的辣根过氧化物酶（HRP）灌注到猫的白质中。水肿液中的灌注蛋白似乎不仅如先前报道的那样通过胞饮作用或吞噬作用被吸收，还能通过毛细血管后微静脉的血管周围间隙迅速被清除。在关闭灌注泵后，诸如HRP等较小的分子在这些间隙中的移动速度比血清白蛋白更快。细胞外液通过血管周围间隙的快速流动可能通过加速扩散在血管源性脑水肿的消退过程中发挥重要作用。
